Figure 4

Quantification by densitometry of 105-kDa pro-MMP-9 (A), and 64-kDa MMP-2 (B) gelatinase activity on zymograms of BAL fluid, performed 1 day or 14 days after intranasal administration of bleomycin (BLM, 0.1 mg/mouse) or saline vehicle (Control), to p47^phox +/+ WT mice (blank bars) and p47^phox -/- KO mice (solid bars). Results are represented as the mean of relative intensity ± SEM. * : p < 0.05, ** : p < 0.01, *** : p < 0.001 compared with control mice exposed to saline solution alone. ###: p < 0.001 for p47^phox -/- KO mice compared with p47^phox +/+ WT mice. n = 8–10.