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Table 2 Effects of nicotine on the production of NO, measured as NOx from A549, AEC, and NHTBE cell lines over 48 hrs. Data are expressed as mean (S.E.M.) % of control of 3 experiments (ANOVA performed on raw data, * p < 0.05 in A549 group; p > 0.05 in AEC and NHTBE groups; Dunnett's multiple comparison test)

From: Effects of cigarette smoke on degranulation and NO production by mast cells and epithelial cells

NOx (Percentage of Control)

Nicotine(μM)

31.25

62.5

125

250

A549 Cell Line

67.0 ± 5.79*

65.0 ± 7.87*

69.8 ± 7.12*

69.4 ± 7.81*

AEC Cells

112.8 ± 25.06

120.2 ± 9.70

105.7 ± 20.68

108.5 ± 22.95

NHTBE Cell Line

87.9 ± 8.61

83.4 ± 10.53

87.9 ± 3.37

99.9 ± 0.07