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Table 4 Disease-specific genes induced in the upper airways

From: dsRNA-induced changes in gene expression profiles of primary nasal and bronchial epithelial cells from patients with asthma, rhinitis and controls

Gene ID

FC rhinitis

p-value rhinitis

FC asthma

p-value asthma

Disease-specific

LAMA3

10.87

<0.001

1.62

0.031

Significant p-value in patients with allergic rhinitis with or without asthma

SH3KBP1

9.12

<0.001

5.13

0.027

NME7

6.44

<0.001

2.68

0.031

ERAP1

5.06

<0.001

3.76

0.026

MFI2

5

<0.001

3.39

0.042

UBASH3B

3.45

<0.001

2.4

0.042

NSD1

3.11

0.001

2.31

0.034

SLC23A2

−3.55

<0.001

−2.22

0.037

ARHGAP5

−3.57

<0.001

−2.12

0.039

ATP6V0A2

−3.79

<0.001

−2.57

0.03

ANKH

−3.96

<0.001

−2.48

0.03

WWTR1

−4.03

<0.001

−2.41

0.048

NEBL

−4.69

0.001

−3.75

0.039

MYO5A

−4.76

<0.001

−2.67

0.033

LAMP2

−5.02

<0.001

−3.05

0.035

AHNAK

−5.02

<0.001

−3.33

0.031

RAB22A

−5.93

<0.001

−3.18

0.031

PPAT

−6.37

<0.001

−2.72

0.044

TFRC

−9.93

<0.001

−5.63

0.028

CCNB2

−15.44

<0.001

−5.37

0.04

IQCG

4.48

0.012

1.07

0.6

In patients with allergic rhinitis

BBS1

−3.23

<0.001

−1.05

0.8

RBM8A

−1.7

0.07

−3.01

0.039

In patients with allergic rhinitis with asthma

SSR1

−2.38

0.2

−3.74

0.044

CLN8

−2.53

0.06

−5.34

0.028

  1. FC = fold change; p-value = p-value adjusted for multiple testing.