There were significant differences among BE and TS groups when compared with NS healthy women. COPD groups did not show any difference: (A) MMP-9. (B) MM9-9/TIMP-1 complex. Relationship between MMP-9 and MM9-9/TIMP-1 complex with the FEV1 (% predicted) in COPD and NS healthy women was performed with the Pearson correlation coefficient (r). (C) MMP-9; r = 0.8037 and p <0.0001; (D) MMP-9/TIMP-1 complex; r = 0.2150 and p <0.0163. Results are expressed as mean ± SD; p <0.01. NS (▪). TS (▲). BE (●).