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Table 2 Adjusted mean differences in lung function responses between tiotropium Respimat® doses

From: Tiotropium Respimat® in asthma: a double-blind, randomised, dose-ranging study in adult patients with moderate asthma

Response parameter

Adjusted mean differences between treatments (95% CI), mL

 

Tiotropium Respimat® 5 μg versus tiotropium Respimat® 1.25 μg

Tiotropium Respimat® 5 μg versus tiotropium Respimat® 2.5 μg

Tiotropium Respimat® 2.5 μg versus tiotropium Respimat® 1.25 μg

FEV1

 Peak FEV1(0-3h)

50 (2, 98)

60 (12, 108)

-10 (-58, 38)

 Trough FEV1

18 (-30, 66)

11 (-36, 59)

7 (-41, 54)

 FEV1 AUC(0-3h)

49 (3, 95)

51 (5, 97)

-2 (-48, 44)

FVC

 Peak FVC(0-3h)

58 (5, 111)

67 (14, 120)

-9 (-61, 44)

 Trough FVC

44 (-15, 103)

27 (-33, 86)

17 (-42, 77)

 FVC AUC(0-3h)

74 (22, 0.125)

63 (11, 114)

11 (-40, 62)

  1. AUC, area under the curve; CI, confidence interval; FEV1, forced expiratory volume in 1 second; FEV1 AUC(0-3h), forced expiratory volume in 1 second area under the curve measured within the first 3 hours after dosing; FVC, forced vital capacity; FVC AUC(0-3h), forced vital capacity area under the curve measured within the first 3 hours after dosing; peak FEV1(0-3h), peak forced expiratory volume in 1 second measured within the first 3 hours after dosing; peak FVC(0-3h), peak forced vital capacity measured within the first 3 hours after dosing.
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Respiratory Research

ISSN: 1465-993X

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