Table 6 Clinical outcomes and hospital resource use
Outcome, n (%) | Early responders n = 332 | Later responders n = 253 | Patients without Halm-based assessment of TCS n = 1454 |
|---|---|---|---|
Antibiotic treatment modification while on initial therapy (excluding streamlining*) | 47 (14.2) | 88 (34.8) | 454 (31.2) |
Time to clinical stability, days, mean (SD) [median] | 2.6 (0.95) [3.0] | 9.0 (6.53) [7.0] | 5.7 (5.0) [5.0] |
Length of stay†, days, mean (SD) [median] | 9.4 (7.0) [8.0] (n = 309) | 15.6 (10.5) [12.0] (n = 246) | 12.6 (10.7) [10.0] (n = 1423) |
Length of stay after achievement of clinical stability‡, days, mean (SD) [median] | 5.9 (7.1) [4.0] (n = 305) | 5.9 (7.0) [3.0] (n = 231) | N/A |
Patients admitted to ICU | 11 (3.3) | 54 (21.3) | 213 (14.6) |
Time in ICU‡, days, mean (SD) [median] (n) | 6.2 (5.7) [4.0] (n = 11) | 10.4 (10.1) [8.0] (n = 53) | 9.5 (12.4) [5.0] |
Patients admitted to ICU after achievement of clinical stability | 0 | 1 (0.4) | N/A |
Reinfection/recurrence§ | 11 (3.3) | 15 (5.9) | 68 (4.7) |
Home-based care after discharge | 6 (1.8) | 11 (4.3) | 56 (3.9) |
Blood pressure support during hospitalization | |||
Fluid resuscitation | 24 (7.2) | 37 (14.6) | 190 (13.1) |
Vasopressors | 2 (0.6) | 17 (6.7) | 82 (5.6) |
Invasive procedures | 1 (0.3) | 3 (1.2) | 26 (1.8) |
Isolation required | 28 (8.4) | 24 (9.5) | 102 (7.0) |
Mechanical ventilation required during hospitalization | 24 (7.2) | 48 (19.0) | 208 (14.3) |
Invasive | 12 (3.6) | 28 (11.1) | 99 (6.8) |
Non-invasive | 12 (3.6) | 25 (9.9) | 129 (8.9) |
Parenteral nutrition | 5 (1.5) | 19 (7.5) | 70 (4.8) |
Duration of parenteral nutrition, days, mean (SD) [median] | 6.0 (3.5) [5.0] (n = 5) | 8.2 (5.1) [6.5] (n = 18) | 9.5 (12.0) [5.0] (n = 65) |
Acute renal failure necessitating renal replacement therapy | 1 (0.3) | 6 (2.4) | 39 (2.7) |
Duration of renal failure, days, mean (SD) [median] | 2.0 (0) [2.0] (n = 1) | 14.3 (16.0) [9.5] (n = 4) | 5.7 (7.2) [3.0] (n = 32) |
Septic shock during hospitalization | 1 (0.3) | 20 (7.9) | 63 (4.3) |
Mortality | 2 (0.6) | 4 (1.6) | 141 (9.7) |
Post-discharge mortality | 0 | 0 | 0 |