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Table 2 Dendritic cell concentrations and characteristics

From: Impact of smoking on dendritic cell phenotypes in the airway lumen of patients with COPD

  Control group (C) n = 10 COPD total group (T) n = 24 COPD current smoker (S) n = 13 COPD former smoker (F) n = 11 C-T p C-S p C-F p S-F p
Blood pDC (*103/ml) 0.64 [0.18…1.40] 0.80 [0.29…1.80] 0.95 [0.45…1.80] 0.68 [0.29…1.60] 0.564 0.284 0.918 0.013
Blood mDC (*103/ml) 1.29 [0.49…1.82] 1.11 [0.54…2.46] 1.09 [0.54…2.14] 1.12 [0.68…2.46] 0.867 0.648 0.863 0.910
BALF recovery (ml) 55.0 [50.0…64.0] 45.5 [27.0…60.0] 47.0 [27.0…60.0] 45.0 [30.0…60.0] 0.007 0.026 0.016 0.608
BALF cell count (*103/ml) 63.0 [21.0…106.0] 86.0 [6.0…530.0] 113.0 [45.0…530.0] 16.0 [6.0…259.0] 0.401 0.010 0.223 0.018
BALF pDC (*103/ml) 0.03 [0.01…0.20] 0.06 [0.0…0.55] 0.07 [0.0…0.55] 0.01 [0.0…0.15] 0.564 0.042 0.251 0.035
BALF pDC (% of all cells) 0.055 [0.01…0.26] 0.07 [0.0…0.25] 0.07 [0.0…0.25] 0.06 [0.03…0.17] 0.956 0.784 0.863 0.910
BALF mDC (*103/ml) 0.60 [0.20…1.62] 0.73 [0.06…4.13] 0.96 [0.21…4.13] 0.16 [0.06…1.68] 0.752 0.057 0.132 0.013
BALF mDC (% of all cells) 1.06 [0.53…1.53] 0.87 [0.32…2.76] 0.76 [0.32…2.76] 0.95 [0.35…1.71] 0.183 0.088 0.605 0.228
BDCA-1+ (% mDC) 58.1 [44.0…69.0] 62.7 [23.0…93.0] 80.1 [52.9…93.0] 43.5 [23.0…64.6] 0.752 0.003 0.006 <0.001
BDCA-3+ (% mDC) 58.8 [55.6…79.5] 57.7 [21.5…82.6] 61.7 [21.5…82.6] 56.8 [37.1…69.0] 0.148 0.313 0.132 0.608
BDCA-4+ (% mDC) 9.5 [3.9…28.6] 26.2 [0.0…68.9] 43.3 [13.8…68.9] 8.1 [0.0…28.9] 0.038 <0.001 0.605 <0.001
CD80+ (% mDC) 56.7 [45.6…73.5] 58.8 [30.0…79.1] 63.1 [44.2…79.1] 45.9 [30.0…60.9] 0.724 0.166 0.020 0.002
CD83+ (% mDC) 38.4 [20.6…45.8] 28.4 [13.4…51.5] 23.7 [13.4.…39.0] 34.2 [21.2…51.5] 0.109 0.010 0.918 0.055
CD86+ (% mDC) 80.3 [67.1…84.5] 85.2 [49.6…96.7] 89.3 [65.9…96.7] 78.0 [49.6…86.2] 0.118 0.004 0.863 0.002
CCR5+ (% mDC) 27.9 [12.3…51.6] 11.1 [1.8…28.8] 10.9 [1.8…28.8] 12.9 [5.7…23.4] 0.001 0.002 0.008 0.865
MMR + (% mDC) 44.9 [30.6…56.1] 53.7 [22.8…84.0] 69.1 [50.6…84.0] 40.4 [22.8…69.2] 0.101 <0.001 0.251 <0.001
Langerin + (% mDC) 32.8 [19.7…51.0] 34.1 [9.4…76.8] 52.6 [28.3…76.8] 20.4 [9.4…44.6] 0.642 0.003 0.013 <0.001
CD1a + (% mDC) 43.5 [29.9…57.6] 56.3 [19.5…82.7] 72.7 [51.1…82.7] 35.6 [19.5…62.1] 0.196 <0.001 0.099 <0.001
RANTES / CCL5 (pg/ml) 10.1 [4.0…66.5] 12.6 [4.0…500.0] 7.5 [4.0…500.0] 14.6 [4.0…49.4] 0.669 0.483 0.973 0.494
  1. Parameters are displayed as median values [minimum…maximum]. Abbreviations denote: Bronchoalveolar Lavage Fluid (BALF), plamacytoid Dendritic Cell (pDC), myeloid Dendritic Cell (mDC), Blood Dendritic Cell Antigen (BDCA), Cluster of Differentiation (CD), Mannose Macrophage Receptor (MMR), Chemokine Receptor (CCR), Regulated on Activation, Normal T Cell Expressed and Secreted (RANTES, also Chemokine Ligand 5, CCL5). The four columns on the right side of the table show comparisons between the groups: Control vs. total group of COPD patients (C-T), Control vs. COPD (current smoker) (C-S), Control vs. COPD (former smoker) (C-F) and COPD (current smoker) vs. COPD (former smoker) (S-F).