Figure 2

Proposed mechanism of BMPR2 downregulation by IL-6. The binding of IL-6 to its receptor triggers the phosphorylation of STAT3. Phosphorylated STAT3 forms a dimer and translocates into the nucleus, where it activates the transcription of the miR-17/92 cluster. The mature miRNA transfers into the cytoplasma and, by binding to the target mRNA, silences BMPR2.