Figure 1

Alveolarization is impaired in JNK-Deficient mice. (A-C) By gross inspection of PND14 lung sections, both JNK1^−/− and JNK2%3^−/− mice had enlarged distal airspaces compared to wild type mice. Scale bar = 20 μm. (D) Compared to wild type lungs, JNK2%3^−/− lungs had larger mean alveolar diameter. (E) Compared to wild type lungs, both JNK1^−/− and JNK2%3^−/− lungs had increased fractional airspace. (F) Both JNK1^−/− and JNK2%3^−/− lungs had decreased numbers of alveolar septa per 20X field. *p < 0.05 compared to wild type by one-way ANOVA. Six animals from two different litters were used for analysis except JNK1^−/− which contained 3 animals from 3 different litters.