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Table 6 Odds ratios for CMH in sex stratified adjusted* analyses of current and former smokers

From: Increased methylation of lung cancer-associated genes in sputum DNA of former smokers with chronic mucous hypersecretion

Males

Current smokers n = 269

Former smokers n = 139

Exposure variable

OR

(95 % CL)

p value

OR

(95 % CL)

p value

Total methylation

1.13

(0.99, 1.30)

0.076

1.39

(1.16, 1.67)

<.0001**

SULF2

2.52

(1.47, 4.32)

0.001**

3.65

(1.59, 8.37)

0.002**

p16

1.36

(0.69, 2.67)

0.378

3.69

(1.42, 9.60)

0.007

JPH3

1.97

(1.02, 3.79)

0.043

4.34

(1.74, 10.79)

0.002**

PCDH20

1.71

(1.02, 2.86)

0.043

2.55

(1.11, 5.83)

0.027

Females

Current smokers n = 560

Former smokers n = 410

Exposure variable

OR

(95 % CL)

p value

OR

(95 % CL)

p value

Total methylation

1.02

(0.93, 1.12)

0.617

1.10

(0.97, 1.24)

0.142

SULF2

1.27

(0.86, 1.88)

0.221

1.92

(1.12, 3.29)

0.019

p16

1.34

(0.83, 2.16)

0.230

1.52

(0.83, 2.80)

0.178

JPH3

0.94

(0.57, 1.56)

0.817

1.40

(0.77, 2.55)

0.272

PCDH20

1.28

(0.87, 1.89)

0.217

1.40

(0.81, 2.42)

0.226

  1. Each row represents a separate adjusted model.
  2. Analysis performed on combined cohorts.
  3. *Additional adjustors include age, education, COPD, pack years, and cohort; CMH as outcome.
  4. **Bonferroni adjusted significance threshold is p < 0.0042.
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Respiratory Research

ISSN: 1465-993X

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