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Table 5 Odds ratios for CMH in adjusted* analyses of current and former smokers

From: Increased methylation of lung cancer-associated genes in sputum DNA of former smokers with chronic mucous hypersecretion

 

LSC former smokers n = 406

PLuSS former smokers n = 155

Combined former smokers n = 561

Exposure variable

OR

(95 % CL)

p value

OR

(95 % CL)

p value

OR

(95 % CL)

p value

Total methylation

1.13

(1.01, 1.26)

0.034

1.36

(1.10, 1.67)

0.004**

1.18

(1.07, 1.30)

0.001**

SULF2

1.96

(1.17, 3.29)

0.011

3.64

(1.51, 8.77)

0.004**

2.30

(1.47, 3.59)

<.0001**

p16

2.06

(1.13, 3.76)

0.018

1.53

(0.59, 3.95)

0.377

1.92

(1.16, 3.17)

0.012

JPH3

1.79

(1.04, 3.09)

0.037

2.76

(0.99, 7.71)

0.053

2.02

(1.25, 3.26)

0.004**

PCDH20

1.9

(1.13, 3.18)

0.015

1.15

(0.46, 2.90)

0.768

1.67

(1.07, 2.61)

0.024

 

LSC current smokers n =  494

PLuSS current smokers n =  335

Combined current smokers n =  829

Exposure variable

OR

(95 % CL)

p value

OR

(95 % CL)

p value

OR

(95 % CL)

p value

Total methylation

1.07

(0.97, 1.17)

0.18

1.07

(0.94, 1.23)

0.303

1.07

(0.99, 1.15)

0.106

SULF2

1.53

(1.03, 2.28)

0.036

1.82

(1.09, 3.04)

0.022

1.60

(1.17, 2.19)

0.003**

p16

1.15

(0.70, 1.89)

0.578

1.83

(0.98, 3.41)

0.057

1.39

(0.95, 2.05)

0.094

JPH3

1.3

(0.84, 1.99)

0.237

1.16

(0.42, 3.19)

0.779

1.29

(0.87, 1.91)

0.200

PCDH20

1.17

(0.79, 1.72)

0.433

1.98

(1.16, 3.36)

0.012

1.39

(1.02, 1.90)

0.039

  1. Each row represents a separate adjusted model.
  2. *Additional adjustors include age, sex, education, COPD, pack years, and cohort (for combined analysis); CMH as outcome.
  3. **Bonferroni adjusted significance threshold is p < 0.0042.