Table 6 Morphometry after elastase instillation and inhibitor treatment
From: Ceramides: a potential therapeutic target in pulmonary emphysema
Parameter | Unit | Control (n=10) | Elastase (n=10) | Elastase + desimaprimine (n=4) | Elastase + zoledronic acid (n=4) | Elastase + sphingolactone (n=4) | Elastase + Myriocin (n=6) |
|---|---|---|---|---|---|---|---|
Mean Linear Intercept | μm | 42.2 (40.8-43.2) | 141.8 (133.3-152.0) | 119.8 (105.8-147.4) | 137.0 (108.1-170.8) | 129.5 (114.8-158.3) | 126.5 (85.6-164.4) |
Tissue-vs-Air ratio | count | 19.9 ± 2.0 | 15.3 ± 2.8* | 13.7 ± 1.3* | 15.7 ± 2.4* | 15.9 ± 2.1* | 18.5 ± 3.1 |