Table 3 Over-represented functional terms
GO cluster | Description | Enrichment score |
|---|---|---|
Genes overexpressed in SSc-ILD vs. Control | ||
1 | Anatomical structure development | 5.50 |
2 | Regulation of cell cycle | 4.23 |
3 | Response to stress and wounding | 3.33 |
Genes underexpressed in SSc-ILD vs. Control | ||
1 | Inflammatory response | 11.53 |
2 | Regulation of cell proliferation | 5.16 |
3 | Regulation of biological process | 5.12 |
4 | Inflammatory response/chemotaxis | 4.81 |
5 | Regulation of cell migration | 4.33 |
6 | Response to external stimulus | 4.19 |
7 | Regulation of apoptosis | 3.78 |
8 | Inflammatory and immune response | 3.77 |
9 | Response to biotic stimulus/ion homeostasis | 3.69 |
10 | Regulation of I-κB kinase/NF-κB cascade | 3.37 |
Genes overexpressed in IPF vs. Control | ||
1 | Anatomical structure development/neurogenesis | 4.94 |
2 | Regulation of apoptosis | 3.95 |
3 | Cell migration/neurogenesis | 3.81 |
4 | Regulation of cell motion | 3.45 |
5 | Response to wounding/tissue development | 3.17 |
6 | Smooth muscle contraction/Blood circulation | 3.03 |
Genes underexpressed in IPF vs. Control | ||
1 | Immune response | 12.65 |
2 | Response to virus, bacteria and LPS | 8.66 |
3 | Positive regulation of biological process and cell death | 5.29 |
4 | Negative regulation of biological process and cell death | 4.91 |
5 | Regulation of immune system and developmental process | 4.08 |
6 | Inflammatory response/chemotaxis | 3.98 |
7 | Regulation of cell migration and adhesion | 3.87 |
8 | Inflammatory and humoral immune response | 3.63 |
9 | Anatomical structure development | 3.39 |
10 | Response to stimulus and I-κB kinase/NF-κB cascade | 3.19 |
11 | Response to extracellular stimulus and oxidative stress | 3.18 |