Figure 5
From: NF-κB activation in myeloid cells mediates ventilator-induced lung injury
Mechanical ventilation induced a significant increase of cytokines/chemokines in WT mice but not in IL-6 antibody-treated WT mice. IL-6 antibody pretreatment decreased high tidal volume ventilation-induced IL-6 levels in the lung (A) and BALF (B) of WT mice. IL-6 antibody pretreatment decreased high tidal volume ventilation-induced IL-1β levels in the lung (C) and BALF (D) of WT mice. *P<0.05, **P<0.01, ***P<0.001. (E) IL-6 antibody treatment decreased high stretch ventilation-induced mRNA expression of proinflammatory cytokines (IL-6, IL-1β) and chemokines (CXCR2, ICAM, MIP-2) in the lung.