Figure 2
From: NF-κB activation in myeloid cells mediates ventilator-induced lung injury
The mechanical ventilator (MV) induced the levels of IL-6 and IL-1β in the lung and BALF. MV significantly increased the production of IL-6 (A, B) and IL-1β (C, D) in the lung and BALF, respectively. *P<0.05, **P<0.01, ***P<0.001. (E) Low tidal volume (Low Vt) or high tidal volume (High Vt) ventilator treatment induced IL-6, IL-1β, and ICAM protein expression in the lung in WT mice. (F) NF-κB DNA binding activity of the lung was increased with the strength of ventilation in WT mice. NS=non-specific binding.