Figure 1
From: NF-κB activation in myeloid cells mediates ventilator-induced lung injury
Mechanical ventilation induced lung injury. The microvascular permeability was increased in ventilator treated WT mice as assayed with extravasation Evans Blue dye (A). The increased neutrophil infiltration (B) was demonstrated by increased myeloperoxidase (MPO) activity in the lung of WT mice with ventilator treatment. Total cell counts (C) and total protein concentration (D) in BALF were increased in WT mice with ventilator treatment. *P<0.05, **P<0.01, ***P<0.001. (E). The extent of neutrophil infiltration and alveolus swelling was observed in WT mice with low tidal volume (Low Vt) or high tidal volume (High Vt) ventilator treatment with HE stain.