Diagnosis of chronic obstructive pulmonary disease in lung cancer screening Computed Tomography scans: independent contribution of emphysema, air trapping and bronchial wall thickening

Table 2 Performance measures for the various multivariate models to identify COPD

	Model	TP	FN	TN	FP	ACC	SENS	SPEC	PPV	NPV
		(n)	(n)	(n)	(n)	(%)	(%)	(%)	(%)	(%)
1	Baseline model ^*	125	312	630	73	66.2	28.6	89.6	63.1	66.9
2	+ CT-BWT	185	252	637	66	72.1	42.3	90.6	73.7	71.7
3	+ CT air trapping	317	120	495	208	71.2	72.5	70.4	60.4	80.5
4	+ CT emphysema	229	208	619	84	74.4	52.4	88.1	73.2	74.8
5	+ CT-BWT	237	200	624	79	75.5	54.2	88.8	75.0	75.7
5	+ CT air trapping	237	200	624	79	75.5	54.2	88.8	75.0	75.7
6	+ CT emphysema	274	163	618	85	78.2	62.7	87.9	76.3	79.1
6	+ CT air trapping	274	163	618	85	78.2	62.7	87.9	76.3	79.1
7	+ CT emphysema	309	128	610	93	80.6	70.7	86.8	76.9	82.7
7	+ CT-BWT	309	128	610	93	80.6	70.7	86.8	76.9	82.7
8	+ CT emphysema	320	117	624	79	82.8	73.2	88.8	80.2	84.2
	+ CT-BWT
	+ CT air trapping

^* Model including age, body mass index, smoking status and packyears of smoking history; TP = true positive; FN = false negative; TN = true negative; FP = false positive; ACC = Accuracy; SENS = Sensitivity; SPEC = Specificity; PPV = Positive predicted value; NPV = Negative predictive value; CT-BWT = Quantitatively assessed bronchial wall thickness.

ISSN: 1465-993X