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Table 9 Small molecular signature for native CF airway epithelial cells

From: Changes in transcriptome of native nasal epithelium expressing F508del-CFTR and intersecting data from comparable studies

Upregulated

ALOX5AP

arachidonate 5-lipoxygenase-activating protein; #241

BCL2A1

BCL2-related protein A1; #597

CXCR4

chemokine (C-X-C motif) receptor 4; #7852

FCGR3A

Fc fragment of IgG, low affinity IIIa, receptor (CD16a); #2214

FOS

FBJ murine osteosarcoma viral oncogene homolog; #2353

G0S2

G0/G1switch 2; #50486

GCNT3

glucosaminyl (N-acetyl) transferase 3, mucin type; #9245

HIST1H1C

histone cluster 1, H1c; #3006

HIST1H2BK

histone cluster 1, H2bk; #85236

IL1B

interleukin 1, beta; #3553

IL1R2

interleukin 1 receptor, type II; #7850

LITAF

lipopolysaccharide-induced TNF factor; #9516

OSM

oncostatin M; #5008

PLEK

pleckstrin; #5341

PTGS2

prostaglandin-endoperoxide synthase 2; #5743

RGS2

regulator of G-protein signaling 2, 24 kDa; #5997

S100A8

S100 calcium binding protein A8; #6279

S100A9

S100 calcium binding protein A9; #6280

SERPINA3

serpin peptidase inhibitor, clade A, member 3; #12

TCN1

transcobalamin I (vitamin B12 bp, R binder family); #6947

TPM4

tropomyosin 4; #7171

Downregulated

CAPS

calcyphosine; #828

CHST9

carbohydrate (N-acet.gal.am. 4–0) sulfotransferase 9; #83539

DNALI1

dynein, axonemal, light intermediate chain 1; #7802

MAOB

monoamine oxidase B; #4129

NELL2

NEL-like 2 (chicken); #4753

PPP1R16A

protein phosphatase 1, regulatory subunit 16A; #84988

PROS1

protein S (alpha); #5627

PTGFR

prostaglandin F receptor (FP); #5737

RAGE

MOK protein kinase; #5891

  1. Regulated genes shared between our study and reanalysed lists from another recent study [19]. Gene symbols, descriptions and Entrez IDs (#) are shown.