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Table 8 Functional enrichment analysis of genes shared between two or three studies

From: Changes in transcriptome of native nasal epithelium expressing F508del-CFTR and intersecting data from comparable studies

Category

Term

Count

%

p

Fold enrichment

FDR

GOTERM_BP_FAT

GO:0006952 defence response

25

13.4

6.00E-07

3.25

0.001

GO:0042060 wound healing

14

7.5

7.37E-07

5.87

0.001

GO:0042127 regulation of cell proliferation

28

15.1

1.37E-06

2.85

0.002

GO:0006955 immune response

25

13.4

4.51E-06

2.90

0.008

GO:0006928 cell motion

20

10.8

6.96E-06

3.37

0.012

GOTERM_CC_FAT

GO:0005576 extracellular region

49

26.3

1.88E-07

2.12

0.000

GO:0044421 extracellular region part

29

15.6

3.41E-06

2.63

0.004

GO:0005615 extracellular space

23

12.4

1.01E-05

2.92

0.013

GO:0000267 cell fraction

27

14.5

2.17E-04

2.17

0.275

GO:0005625 soluble fraction

13

7.0

2.48E-04

3.61

0.314

GOTERM_MF_FAT

GO:0004857 enzyme inhibitor activity

13

7.0

7.39E-05

4.11

0.101

GO:0032395 MHC class II receptor activity

4

2.2

0.001303

17.98

1.768

GO:0004866 endopeptidase inhibitor activity

8

4.3

0.001519

4.71

2.058

GO:0030414 peptidase inhibitor activity

8

4.3

0.002074

4.47

2.800

GO:0005520 insulin-like growth factor binding

4

2.2

0.00294

13.67

3.947

KEGG_PATHWAY

hsa05332: Graft-versus-host disease

8

4.3

2.41E-06

12.42

0.003

hsa04940: Type I diabetes mellitus

8

4.3

4.07E-06

11.53

0.004

hsa05330: Allograft rejection

7

3.8

2.08E-05

11.77

0.023

hsa04610: Complement and coagulation cascades

8

4.3

1.14E-04

7.02

0.126

hsa05416: Viral myocarditis

8

4.3

1.37E-04

6.82

0.151

UP_TISSUE

Lung

52

28.0

5.15E-07

2.03

0.001

  1. The most enriched GO terms found by the DAVID functional annotation tool among the 75 up-regulated and 114 down-regulated genes shared between two or three of the 6 compared studies (see Table 7), showing categories and GO terms enriched, number and percentage of gene lists genes represented in each enriched category, p value, fold enrichment and false discovery rate (FDR).