Table 7 Differentially expressed genes common to two or more of six comparable studies of CF related gene expression

Zabner et al., 2005

UP: ACAA2, CDKN2B.

DOWN: IGFBP2.

Wright et al., 2006

UP: C9orf3, KRT14.

DOWN: CYP24A1, HLA-DQA1, SAA4.

Virella-Lowell et al., 2004

UP: CAV1, CCNE2.

DOWN: CLGN, ENO2, EPB41L3, GPX3, TIMP4.

Verhaeghe et al., 2007

UP: BCL2A1, G0S2, IL1B, MMP1, RGS2.

DOWN: CKB, CRIP1, CYP24A1, DNALI1, FHL1, GSTT1, IGFBP2.

Ogilvie et al., 2011

UP: BCL2A1, G0S2, IL1B, IL1R2, LCP2, NDRG1, RGS2, RNF149, TCN1.

DOWN: PROS1, SCGB1A1, SPAG8.

All shared genes (six studies combined)

UP (n = 75): ACAA2, AGL, AKR1C1, ANXA8L2, BCHE, BLOC1S1, BTBD3, C9ORF3, CAPG, CAV1, CCL20, CCNE2, CD24, CD83, CDKN2B, CLGN, CSF3, DDX3Y, ELK3, FOLR1, FOLR3, FOXG1, GCA, GFPT2, HCLS1, HIST1H1C, HMOX1, HPCAL1, HSPB11, IFIT1, IFIT3, IFITM1, IL1R2, IL7R, ISG15, KCTD12, KRT14, KRT81, LCP2, LITAF, LYPD1, MLF1, MMP1, MRPL28, MX2, NCF1, NDRG1, NET1, PLAU, PLAUR, PLTP, PRSS3, PSG9, PTPN13, RAC2, RAGE, RNF149, RPA3, SEMA3B, SERPINA3, SERPINF1, SLITRK5, SOD2, SULT1A3, TCF15, TCIRG1, TCN1, TXNIP, BCL2A1 , G0S2 , IL1B , NCF2, PLAT, PTGS2, RGS2 .

DOWN (n = 114): ACTA2, ADAR, ALDH1A1, ANKRD1, ASNS, ASS1, BEX4, BST2, BTG1, C5ORF13, CALD1, CAP1, CCL20, CD164, CFB, CGREF1, CKB, CLGN, COL8A1, COL9A3, CRIP1, CSTA, CXCR4, CYP51A1, DDB2, DDIT4, DNALI1, DSP, DSTN, DYNLT1, EDNRA, EFEMP1, EIF4A2, ENO2, EPB41L3, EPS8, F3, FBLN5, FCGBP, FHL1, GABRP, GCH1, GINS1, GPNMB, GPR1, GPX3, GSTT1, GZMB, HCP5, HES1, HLA-B, HLA-DQA1, HLA-DRA, HLA-DRB1, HLA-F, HLA-G, HMGCS1, HSPB1, HTRA1, ID1, IFI16, IFITM1, IFRD1, IGFBP7, IL32, KCNN4, KIT, KLRK1, KRT15, LCN2, LGALS3BP, LOX, MGAM, MSC, NID2, NPR3, NTS, PGD, PNMA2, PPP1R3C, PROS1, RASGRP1, RND3, RUNX3, SAA4, SC5DL, SCGB1A1, SERPINB3, SERPINB4, SGK1, SLC2A3P1, SNAPC1, SPAG8, STAC, STAT4, TES, TFPI, THBD, TIMP4, TPBG, TRIB2, TWIST1, VDAC1, ZNF643, CTSC, CYP24A1 , IFI27, IGFBP2 , IGFBP3, NAMPT, PRSS23, SEL1L3, TMSB4X, TRIM22.