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Table 6 Percentages of genes in common among differentially expressed genes from six microarray studies of CF related gene expression

From: Changes in transcriptome of native nasal epithelium expressing F508del-CFTR and intersecting data from comparable studies

% shared

Z

W

V-L

V

O

C

UP

(N = 300)

(N = 300)

(N = 300)

(N = 300)

(N = 115)

(N = 117)

Z

-

0.7

0.3

1.0

1.7

1.7

W

0.7

-

3.7

5.0

2.6

1.7

V-L

0.3

3.7

-

4.0

2.6

1.7

V

1.0

5.0

4.0

-

14.8

4.3

O

0.7

1.0

1.0

5.7

-

7.7

C

0.7

0.7

0.7

1.7

7.8

-

ALL

3.3

10.0

9.3

15.0

24.3

13.7

DOWN

(N = 300)

(N = 300)

(N = 300)

(N = 300)

(N = 110)

(N = 220)

Z

-

6.7

5.3

3.3

2.7

0.5

W

6.7

-

7.0

2.7

1.8

1.4

V-L

5.3

7.0

-

10.3

2.7

2.3

V

3.3

2.7

10.3

-

0.9

3.2

O

1.0

0.7

1.0

0.3

-

1.4

C

0.3

1.0

1.7

2.3

2.7

-

ALL

13.7

15.7

23.0

17.3

10.9

7.7

% inverted

Z

W

V-L

V

O

C

UP

(N = 300)

(N = 300)

(N = 300)

(N = 300)

(N = 115)

(N = 117)

Z

-

1.3

1

4.3

1.8

0.9

W

7

-

6

5.7

6.4

12.7

V-L

7.7

3.7

-

4.7

1.8

1.4

V

3.7

12.3

13

-

0

1.4

O

1

7

3.3

0

-

1.8

C

1.3

3.7

1.7

1.3

2.7

-

ALL

19.7

25.7

22.3

14.7

11.8

16.8

DOWN

(N = 300)

(N = 300)

(N = 300)

(N = 300)

(N = 110)

(N = 220)

Z

-

7

7.7

3.7

2.6

3.4

W

1.3

-

3.7

12.3

18.3

9.4

V-L

1

6

-

13

8.7

4.3

V

4.3

5.7

4.7

-

0

3.4

O

0.7

2.3

0.7

0

-

2.6

C

0.7

9.3

1

1

3.5

-

ALL

7.3

26

16.7

25.7

27.0

20.5

  1. Percentages are of number of regulated genes in study indicated in horizontal row regulated in the same direction or showing inverted expression in the other five studies as shown at left (Z: Zabner et al., 2005 [17]; W: Wright et al., 2006 [18]; V-L: Virella-Lowell et al., 2004 [16]; V: Verhaeghe et al., 2007 [20]; O: Ogilvie et al., 2011 [19]; C: current study). In each case, ALL refers to total percentage of genes shared or inverted between one study and all five other studies (summarized in Figure 4).