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Table 4 Functional enrichment from DAVID analysis

From: Changes in transcriptome of native nasal epithelium expressing F508del-CFTR and intersecting data from comparable studies

Category

Term

Count

%

P

Fold Enrichment

FDR

GOTERM_BP_FAT (Biological process)

GO:0008285 negative regulation of cell proliferation

14

5.1

6.77 E-04

3.1

1.12

GO:0006953 acute-phase response

5

1.8

1.58 E-03

9.8

2.60

GO:0008202 steroid metabolic process

9

3.3

4.16 E-03

3.5

6.70

GO:0001960 negative regulation of cytokine-mediated signaling pathway

3

1.1

4.23 E-03

29.5

6.81

GO:0042127 regulation of cell proliferation

20

7.3

5.03 E-03

2.0

8.04

GO:0010038 response to metal ion

7

2.5

5.92 E-03

4.3

9.40

GOTERM_ CC_FAT (Cell compartment)

GO:0005929 cilium

10

3.6

3.26 E-05

6.2

0.04

GO:0030286 dynein complex

6

2.2

5.81 E-05

14.1

0.07

GO:0005615 extracellular space

22

8.0

1.16 E-04

2.6

0.15

GO:0005930 axoneme

6

2.2

1.46 E-04

11.7

0.19

GO:0044421 extracellular region part

26

9.5

3.26 E-04

2.2

0.42

GO:0042995 cell projection

21

7.6

4.05 E-04

2.4

0.52

GO:0005856 cytoskeleton

31

11.3

1.63 E-03

1.8

2.08

GO:0005875 microtubule associated complex

7

2.5

1.70 E-03

5.5

2.16

GO:0044430 cytoskeletal part

23

8.4

3.48E-03

1.9

4.39

GO:0035085 cilium axoneme

4

1.5

3.55 E-03

12.8

4.48

GO:0005576 extracellular region

39

14.2

4.51 E-03

1.6

5.65

GOTERM_MF_FAT (Molecular Function)

GO:0003777 microtubule motor activity

6

2.2

2.95 E-03

6.1

4.03

GO:0005509 calcium ion binding

23

8.4

2.98 E-03

2.0

4.07

UP_TISSUE

Lung

63

22.9

6.08 E-06

1.8

0.01

Testis

80

29.1

2.59 E-03

1.3

3.06

Trachea

13

4.7

7.16 E-03

2.4

8.26

Plasma

11

4.0

7.45 E-03

2.7

8.58

  1. The most enriched GO terms found following submission of our gene list to the DAVID functional annotation tool, showing categories and GO terms enriched, number and percentage of gene lists genes represented in each enriched category, significance level (P), fold enrichment and false discovery rate (FDR).