Smoking decreases the response of human lung macrophages to double-stranded RNA by reducing TLR3 expression

Respiratory Research

Table 3 Characteristics of surgical lung tissue subjects

Group	Smokers with COPD	Smokers without COPD	pvalue
Subjects, n	18	7
Sex ratio, M/F	10/8	5/2	0.49
Age, years (SD)	61.8 (9.4)	54.4 (9.1)	0.74
Smoking, pack-years (SD)	60.3 (41.4)	44.5 (23.9)	0.47
Smoking status (Former/Current)	4/14	3/4	0.11
FEV₁, % pred. (SD)	41.8 (27.7)	95.4 (11.2)	0.0008
FEV1/FVC% (SD)	42.5 (18.6)	76.0 (5.2)	0.0002
ICS use (yes/no)	12/6	1/6	0.02

ICS Inhaled Corticosteroid Use, M Male, F Female. Data are represented as mean (SD), ratio of current smokers to former smokers, or fraction of ICS users (yes/no). All FEV1 values are pre-bronchodilator. p values calculated using Mann Whitney test.

ISSN: 1465-993X