Figure 1

AIM expression in alveolar macrophages in lung tissues. Immunohistochemical staining of AIM in AM in lung tissues from non-smoker, non-COPD smoker, and COPD patients: Photomicrographs of non-smoker lung (A and B), non-COPD smoker lung (C and D), and COPD lung tissues (E and F). (G) Shown is the average total number of AM (±SEM) in five randomly selected lung fields in high power field (HPF) (X400) from five cases. Open bar is non-smoker, filled bar is non-COPD smoker, and horizontal crosshatched bar is COPD. *p < 0.05, **p < 0.001. (H) Shown is the average ± SEM of percentages of AIM positive cells in total cells in HPF (X400) from five cases. Open bar is non-smoker, filled bar is non-COPD smoker, and horizontal crosshatched bar is COPD. **p < 0.001. (I) Shown is the relationship between number of AM and percentages of AIM positive cells. Bar = 200 μm in A, C, and E. Bar = 50 μm in B, D, and F.