Figure 4

No involvement of prostaglandin D ₂ - or leukotriene B ₄ on poly IC-induced augmentation of airway eosinophilia. The eosinophilia in BALF after OVA challenge was measured for the mice sensitized with OVA in the following conditions (A to C). OVA challenge was performed two weeks after the last OVA sensitization. (A) Wild-type BALB/c mice and BLT-1^−/− mice were treated with poly IC or saline alone before each OVA sensitization. (B) Kit^W/Kit^W-v mice were transferred with BMMCs from wild-type C57BL/6 mice or hPGD₂S^−/−mice. Five weeks after the transfer, mice were treated with poly IC or saline alone before each OVA sensitization. (C) BALB/c mice were treated with poly IC or saline alone before each OVA sensitization. HQL-79, a selective inhibitor of hPGD₂S, was administered just before each poly IC treatment. Data are expressed as the means ± SEM. Each group consisted of six mice. *P < 0.05 between the indicated two groups.