Figure 3

Effect of TRIF/IRF-3 deficiency in mast cells on poly IC-induced augmentation of airway eosinophilia. Kit^W/Kit^W-v mice were transferred with BMMCs from C57BL/6 mice, TRIF^−/−mice, or IRF-3^−/−mice. Five weeks after the transfer, mice were treated with poly IC or saline alone before each OVA sensitization. Two weeks later, the mice were challenged with OVA, and the eosinophilia in BALF was measured. Each group consisted of five to eight mice. Data are expressed as the means ± SEM. *P < 0.05 between the indicated two groups.