Figure 2

Role of TRIF, IPS-1, and IRF-3 in poly IC-induced augmentation of airway eosinophilia. (A) Naive C57BL/6 mice, TRIF^−/−mice, IPS-1^−/−mice, and IRF-3^−/−mice were treated with poly IC. The sera were collected five hours after poly IC, and the IFN-β and IL-6 contents were then measured by ELISA. Each group consisted of five to nine mice. (B) C57BL/6 mice, TRIF^−/−mice, IPS-1^−/−mice, and IRF-3^−/−mice were treated with poly IC or saline alone before each OVA sensitization. Two weeks later, mice were challenged with OVA, and the eosinophilia in BALF was measured. Each group consisted of five to nine mice. Data are expressed as the means ± SEM. *P < 0.05 between the indicated two groups.