Figure 7

Development of hypoxic pulmonary arterial hypertension following IUGR. Maternal nutrient restriction increased the histone acetylation and transcription factor HIF-1α binding levels in the ET-1 gene promoter of pulmonary vascular endothelial cells (PVEC) in IUGR rats. These epigenetic changes would induce IUGR individual in later life to be highly sensitive to hypoxia, resulting in more significant pulmonary hypertension (B). AC = (Histone) acetylation, SMC = smooth muscle cells, PAH = pulmonary arterial hypertension.