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Table 3 Sputum mediator concentrations for subjects stratified by the median RB1 total area and luminal area

From: Sputum mediator profiling and relationship to airway wall geometry imaging in severe asthma

  Total Low total area High total area p value Low luminal area High luminal area p value
Factor VII* 2.15 [1.89-2.43] 2.03 [1.69-2.44] 2.27 [1.89-2.72] 0.40 2.01 [1.68-2.41] 2.30 [1.91-2.77] 0.25
Fibrinogen* 240 [172–335] 260 [161–421] 223 [137–364] 0.48 291 [184–461] 200 [121–330] 0.16
Ferritin* 2.21 [1.54-3.17] 2.56 [1.62-4.06] 1.94 [1.10-3.42] 0.38 2.21 [1.35-3.61] 2.21 [1.27-3.85] 0.9
IL-1 α 27 [19-37] 35 [23–54] 20 [12-33] 0.13 38 [25–58] 19 [12-30] 0.041
IL-1 β 47 [31–71] 44 [26–76] 49 [25–96] 0.40 45.4 [26.72-77.14] 48.8 [25–95.4] 0.40
IL-1RA 6951 [5168–9350] 8147 [5120–12964] 5962 [4033–8815] 0.59 9108 [5752–14421] 5353 [3662–7824] 0.19
IL-6 41 [30–56] 32 [20–53] 52 [35–76] 0.14 33.3 [20.5-54.1] 51.8 [35.3-76.1] 0.16
IL-8 3608 [2462–5287] 2846 [1599–5064] 4537 [2686–7665] 0.37 3062 [1790–5237] 4227 [2393–7469] 0.43
IL-15 440 [370–520] 410 [320–540] 460 [360–600] 0.60 410 [320–540] 460 [360–600] 0.60
IL-18 40.2 [32.2-50.2] 37.2 [27–51.3] 43.3 [31.2-6] 0.31 39.2 [27.7-55.5] 41.2 [30.5-55.6] 0.53
TNF-α 6.46 [4.58-9.12] 4.66 [3.45-7.30] 9.35 [3.91-17.8] 0.09 4.71 [3.48-6.36] 9.25 [4.84-17.6] 0.06
TNFR2 330 [230–490] 280 [160–510] 390 [220–670] 0.46 290 [160–500] 390 [220–680] 0.39
CCL2 100 [75–134] 96 [62–150] 105 [71–156] 0.35 100 [65–153] 101 [67–153] 0.98
CCL4 462 [313–682] 380 [241–600] 554 [291–1052] 0.42 349 [220–555] 611 [322–1158] 0.036
CCL11 59.8 [48.4-73.9] 48.3 [39.2-59.6] 76.3 [52.4-111] 0.026 49.1 [39.7-60.7] 74.9 [51.3-109] 0.043
MMP-3* 0.25 [0.19-0.33] 0.27 [0.18-0.40] 0.23 [0.16-0.33] 0.51 0.26 [0.18-0.39] 0.24 [0.16-0.34] 0.56
MMP-9* 38.1 [26.7-54.3] 48.8 [29.1-81.8] 30.3 [18.3-50] 0.11 50.8 [31.6-81.7] 29.1 [17.1-49.5] 0.09
TIMP-1* 108 [78.6-14] 93 [56–155] 124 [82–188] 0.33 98 [60–159] 118 [75–185] 0.40
ICAM-1 2900 [2170–3870] 2490 [1650–3740] 3370 [2200–5150] 0.32 2400 [1620–3550] 3530 [2280–5460] 0.19
VCAM-1 1130 [850–1490] 1240 [830–1860] 1003 [690–1560] 0.80 1200 [820–1760] 1060 [690–1630] 0.78
VEGF 837 [678–1033] 793 [592–1061] 882 [640–1214] 0.51 823 [617–1098] 851 [616–1175] 0.83
  1. All units are pg/ml except *denoting ng/ml, data represented as Geometric mean [95% CI].