Table 3 Sputum mediator concentrations for subjects stratified by the median RB1 total area and luminal area

Factor VII*

2.15 [1.89-2.43]

2.03 [1.69-2.44]

2.27 [1.89-2.72]

0.40

2.01 [1.68-2.41]

2.30 [1.91-2.77]

0.25

Fibrinogen*

240 [172–335]

260 [161–421]

223 [137–364]

0.48

291 [184–461]

200 [121–330]

0.16

Ferritin*

2.21 [1.54-3.17]

2.56 [1.62-4.06]

1.94 [1.10-3.42]

0.38

2.21 [1.35-3.61]

2.21 [1.27-3.85]

0.9

IL-1 α

27 [19-37]

35 [23–54]

20 [12-33]

0.13

38 [25–58]

19 [12-30]

0.041

IL-1 β

47 [31–71]

44 [26–76]

49 [25–96]

0.40

45.4 [26.72-77.14]

48.8 [25–95.4]

0.40

IL-1RA

6951 [5168–9350]

8147 [5120–12964]

5962 [4033–8815]

0.59

9108 [5752–14421]

5353 [3662–7824]

0.19

IL-6

41 [30–56]

32 [20–53]

52 [35–76]

0.14

33.3 [20.5-54.1]

51.8 [35.3-76.1]

0.16

IL-8

3608 [2462–5287]

2846 [1599–5064]

4537 [2686–7665]

0.37

3062 [1790–5237]

4227 [2393–7469]

0.43

IL-15

440 [370–520]

410 [320–540]

460 [360–600]

0.60

410 [320–540]

460 [360–600]

0.60

IL-18

40.2 [32.2-50.2]

37.2 [27–51.3]

43.3 [31.2-6]

0.31

39.2 [27.7-55.5]

41.2 [30.5-55.6]

0.53

TNF-α

6.46 [4.58-9.12]

4.66 [3.45-7.30]

9.35 [3.91-17.8]

0.09

4.71 [3.48-6.36]

9.25 [4.84-17.6]

0.06

TNFR2

330 [230–490]

280 [160–510]

390 [220–670]

0.46

290 [160–500]

390 [220–680]

0.39

CCL2

100 [75–134]

96 [62–150]

105 [71–156]

0.35

100 [65–153]

101 [67–153]

0.98

CCL4

462 [313–682]

380 [241–600]

554 [291–1052]

0.42

349 [220–555]

611 [322–1158]

0.036

CCL11

59.8 [48.4-73.9]

48.3 [39.2-59.6]

76.3 [52.4-111]

0.026

49.1 [39.7-60.7]

74.9 [51.3-109]

0.043

MMP-3*

0.25 [0.19-0.33]

0.27 [0.18-0.40]

0.23 [0.16-0.33]

0.51

0.26 [0.18-0.39]

0.24 [0.16-0.34]

0.56

MMP-9*

38.1 [26.7-54.3]

48.8 [29.1-81.8]

30.3 [18.3-50]

0.11

50.8 [31.6-81.7]

29.1 [17.1-49.5]

0.09

TIMP-1*

108 [78.6-14]

93 [56–155]

124 [82–188]

0.33

98 [60–159]

118 [75–185]

0.40

ICAM-1

2900 [2170–3870]

2490 [1650–3740]

3370 [2200–5150]

0.32

2400 [1620–3550]

3530 [2280–5460]

0.19

VCAM-1

1130 [850–1490]

1240 [830–1860]

1003 [690–1560]

0.80

1200 [820–1760]

1060 [690–1630]

0.78

VEGF

837 [678–1033]

793 [592–1061]

882 [640–1214]

0.51

823 [617–1098]

851 [616–1175]

0.83