SiRNA mediated knockdown of ATF6α and ERp57 decreases HDM-induced airway hyperresponsiveness. Assessment of airway mechanics using a forced oscillation technique. Measurement of Newtonian Resistance (Rn) (A), airflow heterogeneity or tissue resistance (G) (B), and airway closure/elastance (H) (C), in response to varying doses of methacholine. *p < 0.05 by ANOVA, denotes differences in peak responses, compared with PBS controls. #p < 0.05 by ANOVA, denotes differences in peak responses, compared with the HDM groups (n = 10 mice/group).