The unique alterations of hippocampus and cognitive impairment in chronic obstructive pulmonary disease

Respiratory Research

Table 4 Relationships between the relative test values and MMSE score in the groups with COPD of different severity

Test parameter	Mild-to-moderate COPD group MMSE (n = 37)		Severe COPD group MMSE (n = 48)		Total COPD group MMSE (n = 85)
	r	P	r	P	r	P
PaO₂	0.59	<0.01	0.46	<0.01	0.54^a	<0.01
PaCO₂	0.12	NS	−0.11	NS	−0.16^a	NS
SaO₂	0.21	NS	0.37^a	<0.01	0.36^a	<0.01
FVC	0.18	NS	0.17	NS	0.39	<0.01
FEV₁	0.25	NS	0.35	<0.05	0.49^a	<0.01
FEV₁/FVC	0.03	NS	0.13	NS	0.31^a	<0.05
S100B	−0.40	<0.05	−0.31	<0.05	−0.52	<0.01

FEV₁ = forced expiratory volume in one second; FVC = forced vital capacity; PaO₂ = arterial oxygen tension; PaCO₂ = arterial carbon dioxide tension; SaO₂ = blood oxygen saturation; MMSE = mini mental state exam; NS = no significant correlations. r = Pearson Correlation coefficient (except where indicated otherwise); ^a: Spearman rank correlation coefficient.

ISSN: 1465-993X