Skip to main content

Table 3 Effect of ozone on FEF 25-75 , according to the number of risk alleles and vitamin C &

From: Ozone exposure, vitamin C intake, and genetic susceptibility of asthmatic children in Mexico City: a cohort study

  30–105 mg/day >105–477 mg/day  
Risk Alleles n Coeff(95% CI) n Coeff(95% CI) Diet effectπ
All asthmatics
1 to 3 30 24.0 (−50.0, 98.1) 73 27.0 (−16.5, 70.5) 3.0 (−82.2, 88.2)
4 to 6 30 −58.8 (−122.3, 0.1) £ 66 −16.8 (−49.7, 16.1) 42.0(−24.0, 108.0)
Genotype effect Ω   −82.8 (−180.0, 15.0) £   −43.8 (−98.4, 11.4)  
Persistent asthmatics
1 to 3 18 19.2 (−67.8, 106.2) 50 15.6 (−35.0, 66.2) −3.6 (−105.6, 98.4)
4 to 6 19 97.2 (−185.4, -9.0) € 50 −18.6 (−58.6, 21.4) 78.6 (77.1, 80.1) £
Genotype effect   −116.4 (−118.4, -114.4) £   −34.2 (−98.4, 30.0)  
  1. Models were adjusted for gender, age, BMI, height, chronological time, cohort, use of bronchodilator, and minimum temperature. All asthmatics: n = 199 and 3842 repeated measures; persistent (mild, moderate or severe) asthmatics: n = 137 and 2715 repeated measures.
  2. € p ≤ 0.05; £ 0.05 < p ≤ 0.1; Ω Genotype effect is defined to be the change in response produced by a change in the level of genotype.
  3. Π Diet effect is defined to be the change in response produced by a change in the level of diet intake. &FEF25-75 is reported as ml/s per 1-h 60 ppb on the day prior to spirometric test.