Skip to main content

Table 6 Multivariate analysis of prognostic survival factors for 2nd and 3rd line therapy

From: Treatment and outcome of patients with metastatic NSCLC: a retrospective institution analysis of 493 patients

  Survival after 2nd line therapy Survival after 3rd line therapy
  HR 95% CI p-value HR 95% CI p-value
Age    0.011    0.034
< 70 years 1    1   
≥ 70 years 0.61 0.41-0.89   0.54 0.31-0.95  
Smoking status    >0.1    0.033
Never smoker   0.35 0.17-0.74  
Former smoker   0.59 0.35-0.98  
Current smoker   1   
Unknown   0.72 0.38-1.36  
Histology    0.076    >0.1
Adenocarcinoma 0.64 0.42-0.96   
Squamous cell carcinoma 0.61 0.35-1.05   
Large cell undifferentiated carcinoma 1     
Response to previous therapy line    0.003    >0.1
Disease control 0.60 0.42-0.84   
Progress 1     
Response to both previous therapy lines    NA    < 0.001
Disease control in both previous lines   0.29 0.14-0.59  
Disease control in any previous line   0.73 0.38-1.40  
Progress in both previous lines   1   
  1. HR, hazard ratio; CI, confidence interval.
  2. “─” indicates that data could not be calculated.