Table 6 Multivariate analysis of prognostic survival factors for 2nd and 3rd line therapy
Survival after 2nd line therapy | Survival after 3rd line therapy | |||||
|---|---|---|---|---|---|---|
HR | 95% CI | p-value | HR | 95% CI | p-value | |
Age | 0.011 | 0.034 | ||||
< 70 years | 1 | 1 | ||||
≥ 70 years | 0.61 | 0.41-0.89 | 0.54 | 0.31-0.95 | ||
Smoking status | >0.1 | 0.033 | ||||
Never smoker | ─ | ─ | 0.35 | 0.17-0.74 | ||
Former smoker | ─ | ─ | 0.59 | 0.35-0.98 | ||
Current smoker | ─ | ─ | 1 | |||
Unknown | ─ | ─ | 0.72 | 0.38-1.36 | ||
Histology | 0.076 | >0.1 | ||||
Adenocarcinoma | 0.64 | 0.42-0.96 | ─ | ─ | ||
Squamous cell carcinoma | 0.61 | 0.35-1.05 | ─ | ─ | ||
Large cell undifferentiated carcinoma | 1 | ─ | ||||
Response to previous therapy line | 0.003 | >0.1 | ||||
Disease control | 0.60 | 0.42-0.84 | ─ | ─ | ||
Progress | 1 | ─ | ||||
Response to both previous therapy lines | NA | < 0.001 | ||||
Disease control in both previous lines | ─ | ─ | 0.29 | 0.14-0.59 | ||
Disease control in any previous line | ─ | ─ | 0.73 | 0.38-1.40 | ||
Progress in both previous lines | ─ | ─ | 1 | |||