Figure 1

Study design. After a screening visit (visit 1) treatment period 1 was comprised of visits 2 and 3 and treatment period 2 was comprised of visits 4 and 5. Eligible randomized subjects returned to the clinic (visit 2) 7–21 days following visit 1 and were dosed with either 300 mg AZD8309 or placebo at 09:00 hours and were discharged with instructions for continued dosing at home. Subjects returned for LPS challenge the following morning (visit 3). Six hours post-completion of the LPS inhalation, subjects produced an induced sputum sample. There was a washout period between visits 3 and 4 of at least 21 days. Treatment period 2 was structured the same as treatment period 1.