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Table 2 Comparison of various parameters according to each HRCT patterns

From: Serum heat shock protein 47 levels in patients with drug-induced lung disease

 

OP

NSIP

HP

DAD

Pvalue

 

(N = 4)

(N = 24)

(N = 11)

(N = 8)

 
   

[n]

  

[n]

  

[n]

  

[n]

 

Hematologic data

             

  WBC (/mm3)

10600

(4300-14600)

[4]

6400

(3500-11200)

[23]

6700

(3500-13400)

[11]

10450#

(4900-20800)

[8]

0.01

  Hb (g/dL)

10.6

(7.9-13.6)

[4]

11.7

(8.5-16.2)

[23]

12.0

(8.6-14.4)

[11]

11.4

(8.6-12.2)

[8]

N.S.

  Plt (×104/mm3)

25.4

(17.8-31.1)

[4]

22.6

(9.7-45.5)

[23]

26.3

(12.5-33.1)

[11]

24.6

(8.9-46.9)

[8]

N.S.

Serum markers

             

  KL-6 (U/mL)

293.0

(144-311)

[3]

902.0

(320-3884)

[22]

518.5

(264-3697)

[10]

442.0

(147-2218)

[7]

0.03§

  SP-A (ng/mL)

48.5

(42.6-54.4)

[2]

50.5

(35.9-219)

[19]

98.5

(47.1-310)

[10]

115.0

(43.4-169)

[5]

0.04§

  SP-D (ng/mL)

40.0

(33-169)

[3]

193.0

(23-753)

[20]

186.5

(56.2-532)

[10]

168.0

(60.0-462)

[7]

N.S.

  HSP47 (pg/mL)

301.1

(100.5-985.7)

[4]

554.4

(61.9-1356)

[24]

847.9

(347.7-2012)

[11]

1868.3*

(816.3-2843.9)

[8]

<0.001

Respiratory parameters

  

[4]

  

[21]

  

[11]

  

[8]

 

  P/F ratio (mmHg)

397.9

(370.9-475.2)

 

393.8

(260-523.8)

 

355.7

(83.1-542.9)

 

150.7*

(71-293.8)

 

<0.001

  A-a DO2 (mmHg)

13.5

(4.3-32.3)

 

18.9

(−11.3-69.1)

 

36.3

(−9.5-450.0)

 

214.8*

(42.4-474.7)

 

<0.001

BAL fluid findings

  

[4]

  

[22]

  

[9]

  

[5]

 

  Total cell count (× 105/mL)

6.29

(3.6-27.2)

 

4.66

(1.44-54.9)

 

9.01

(1.8-15.5)

 

5.28

(1.27-8.9)

 

N.S.

  Macrophages (%)

57.2

(28.9-73.6)

 

57.9

(4.6-85.6)

 

33.8

(4.2-82.7)

 

32.8

(4.0-94.8)

 

N.S.

  Lymphocytes (%)

29.6

(22.9-52.9)

 

26.6

(1.7-77.8)

 

54.8

(13.7-95.4)

 

31.3

(1.9-47)

 

N.S.

  Neutrophils (%)

3.8

(0.6-6.9)

 

2.5

(0-93.6)

 

3.5

(0-15.8)

 

32.1

(0.4-52)

 

N.S.

  Eosinophils (%)

0.8

(0.5-29.9)

 

2.7

(0-50.9)

 

1.6

(0-15.5)

 

2.0

(0-2.88)

 

N.S.

  CD4/8 ratio

1.5

(0.36-2.22)

 

1.8

(0.14-7.5)

 

0.83

(0.14-10.4)

 

1.08

(0.4-1.4)

 

N.S.

  1. Data are presented as medians (range). N = number of patients; n = number of patients examined; OP = organizing pneumonia pattern; NSIP = nonspecific interstitial pneumonia pattern; HP = hypersensitivity pneumonitis pattern; DAD = diffuse alveolar damage pattern; N.S. = not significant; WBC = white blood cell count; Hb = hemoglobin; Plt = platelet count; KL-6 = Krebs von den Lungen-6; SP-A = surfactant protein-A; SP-D = surfactant protein-D; HSP47 = heat shock protein 47; P/F ratio = PaO2/fraction of inspired oxygen ratio; A-a DO2 = alveolar-arterial difference of oxygen; BAL = bronchoalveolar lavage; CD4/8 ratio = CD4/CD8 ratio of lymphocyte subsets. #; p < 0.01 compared with NSIP and HP group. *; p < 0.01 compared with OP, NSIP, and HP group. §; Significantly different among the groups; however, pair-wise comparison by post-hoc analysis did not show any significant difference between any pairs.
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Respiratory Research

ISSN: 1465-993X

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