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Table 1 Comparison of patient characteristics according to each HRCT pattern

From: Serum heat shock protein 47 levels in patients with drug-induced lung disease

 

OP

NSIP

HP

DAD

Pvalue

 

(N = 4)

(N = 24)

(N = 11)

(N = 8)

 

Age (years)

71.5

(68-77)

68.0

(34-84)

64.0

(48-79)

69.5

(62-80)

N.S.

Sex (male/female)

2/2

 

18/6

 

5/6

 

5/3

 

N.S.

Smoking (s/ex/n)

0/3/1

 

2/16/6

 

0/6/5

 

3/3/2

 

N.S.

Duration from HRCT chest scanning to the serum sample collection (days)

1

(1–3)

4.5

(0–21)

3

(0–16)

2

(0–20)

N.S.

Causal drugs

        

N.S.

  Cytotoxic agents

0

 

8

 

1

 

2

  

  DMARDs

1

 

4

 

3

 

0

  

  Chinese herbal medicine

1

 

1

 

0

 

4

  

  Antineoplastic agent

0

 

3

 

2

 

0

  

  NSAIDs

1

 

2

 

0

 

1

  

  Antibiotics

1

 

0

 

2

 

0

  

  Interferon

0

 

1

 

1

 

0

  

  Others

0

 

5

 

2

 

1

  

Improved without GC administration (%)

75.0

 

45.8

 

36.4

 

0*

 

0.05

Ventilator needed (%)

0.0

 

0.0

 

0.0

 

37.5#

 

0.001

Mortality rate at 30 days (%)

0.0

 

0.0

 

0.0

 

37.5#

 

0.001

  1. Data presented as median (range).
  2. N = number of patients; OP = organizing pneumonia pattern; NSIP = nonspecific interstitial pneumonia pattern; HP = hypersensitivity pneumonitis pattern; DAD = diffuse alveolar damage pattern; N.S. = not significant; s/ex/n = current smoker/ex-smoker/nonsmoker; HRCT = high-resolution computed tomographic; DMARDs = Disease-modifying anti-rheumatic drugs; NSAIDs = non-steroidal anti-inflammatory drugs; GC = glucocorticoid. *; p < 0.01 compared with OP group. p < 0.05 compared with NSIP group. #; p < 0.01 compared with NSIP group. p < 0.05 compared with HP group.
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Respiratory Research

ISSN: 1465-993X

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