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Table 4 Results of base case NMA: Difference in intervention versus the comparator for SGRQ responders at 6 months in terms of odds ratios (ORs), 95% credible intervals, and probability that the intervention is better than the comparator

From: Comparative efficacy of long-acting bronchodilators for COPD - a network meta-analysis

  

Comparator

Intervention

 

PLACEBO

TIO 18

SAL 50

FOR 12

TIO 5

IND 150

IND 300

GPM 50

PLACEBO

estimate

1.00

0.71

0.84

0.71

0.70

0.60

0.67

0.69

95% CrI

  

0.61

0.83

0.70

1.00

0.48

1.07

0.49

1.00

0.47

0.77

0.52

0.87

0.52

0.92

P(better)

  

<1%

9%

5%

3%

<1%

<1%

1%

TIO 18

estimate

1.41

1.00

1.20

1.01

0.99

0.84

0.95

0.97

95% CrI

1.21

1.64

  

0.92

1.58

0.65

1.58

0.66

1.50

0.64

1.14

0.71

1.29

0.71

1.35

P(better)

>99%

  

92%

52%

48%

11%

35%

43%

SAL 50

estimate

1.19

0.84

1.00

0.84

0.83

0.71

0.79

0.81

95% CrI

1.00

1.42

0.63

1.09

  

0.53

1.34

0.54

1.27

0.52

0.96

0.57

1.11

0.56

1.17

P(better)

91%

8%

  

22%

15%

2%

8%

12%

FOR 12

estimate

1.40

0.99

1.18

1.00

0.98

0.84

0.94

0.96

95% CrI

0.93

2.10

0.63

1.55

0.74

1.90

  

0.58

1.68

0.53

1.33

0.63

1.42

0.59

1.58

P(better)

95%

48%

78%

  

47%

20%

36%

44%

TIO 5

estimate

1.42

1.01

1.20

1.02

1.00

0.85

0.95

0.98

95% CrI

1.00

2.03

0.67

1.52

0.79

1.87

0.60

1.74

  

0.56

1.32

0.63

1.49

0.62

1.55

P(better)

97%

52%

85%

53%

  

19%

39%

46%

IND 150

estimate

1.67

1.19

1.42

1.20

1.18

1.00

1.12

1.15

95% CrI

1.29

2.13

0.88

1.57

1.04

1.92

0.75

1.88

0.76

1.79

  

0.83

1.51

0.78

1.67

P(better)

>99%

89%

98%

80%

81%

  

79%

79%

IND 300

estimate

1.49

1.06

1.26

1.07

1.05

0.89

1.00

1.03

95% CrI

1.15

1.91

0.78

1.41

0.90

1.76

0.71

1.59

0.67

1.60

0.66

1.20

  

0.70

1.49

P(better)

>99%

65%

92%

64%

61%

21%

  

56%

GPM 50

estimate

1.45

1.03

1.23

1.04

1.02

0.87

0.97

1.00

95% CrI

1.08

1.94

0.74

1.42

0.85

1.79

0.63

1.71

0.65

1.61

0.60

1.27

0.67

1.43

  

P(better)

99%

57%

88%

56%

54%

21%

44%

  
  1. 95% CrI = 95% Credible Interval; P(better) = Probability of being the treatment being better than the comparator in terms of the outcome assessed; FOR 12 = Formoterol 12 μg twice daily (BID); GPM 50 = Glycopyrronium 50 μg once daily (OD); IND 150 = Indacaterol 150 μg OD; IND 300 = Indacaterol 300 μg OD; OR = Odds ratio; SAL 50 = Salmeterol 50 μg BID; SGRQ = St. George’s Respiratory Questionnaire; TIO 5 = Tiotropium 5 μg OD; TIO 18 = Tiotropium 18 μg OD.
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Respiratory Research

ISSN: 1465-993X

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