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Table 1 Effect of SNAP on GM-CSF-induced eosinophil survival as previously described[12]

From: Nitric oxide-induced eosinophil apoptosis is dependent on mitochondrial permeability transition (mPT), JNK and oxidative stress: apoptosis is preceded but not mediated by early mPT-dependent JNK activation

 

Apoptotic cells (%)

Untreated

60.8 ± 4.1

GM-CSF 10 pM

11.1 ± 1.6

 +SNAP 10 μM

10.5 ± 1.8

 +SNAP 100 μM

28.4 ± 10.9

 +SNAP 1000 μM

44.6 ± 8.6 **

GM-CSF 10 pM

9.3 ± 1.0

 +Penicillamine 100 μM

8.6 ± 1.2

 +Penicillamine 1000 μM

8.6 ± 2.1

  1. Apoptosis was determined after 40 h of incubation by DNA fragmentation assay. Shown are mean ± SEM, n = 7. ** indicates p < 0.01 as compared with GM-CSF-treated cells.
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Respiratory Research

ISSN: 1465-993X

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