Figure 1
From: Effects of hypercapnia and NO synthase inhibition in sustained hypoxic pulmonary vasoconstriction
Effects of hypercapnia with or without acidosis on changes in pulmonary arterial pressure (ΔPAP) during hypoxia, and normoxia. A. Changes of PAP in hypoxic normocapnia (n = 7), hypoxic hypercapnic acidosis (n = 7), and hypoxic hypercapnia without acidosis (n = 8) during 180 min of hypoxic ventilation, followed by 10 min ventilation with normoxic normocapnic gas (recovery). ΔPAP: change of PAP referenced to the baseline value at time set at zero. B. Changes of PAP in normoxic normocapnia (n = 8), normoxic hypercapnic acidosis (n = 8) and normoxic hypercapnia without acidosis (n = 7) during 190 min normoxic ventilation. ΔPAP: change of PAP referenced to the value at time set at zero. All data are mean ± SEM. *, significant difference (P < 0.05) between hypoxic normocapnia and hypoxic hypercapnic acidosis. #, significant difference (P < 0.05) between hypoxic normocapnia and hypoxic hypercapnia without acidosis. §, significant difference (P < 0.05) between hypoxic hypercapnic acidosis and hypoxic hypercapnia without acidosis.