HSULF-1 inhibits ERK and AKT signaling and decreases cell viability in vitro in human lung epithelial cells

Respiratory Research

Table 1 Genes that were up- or down-regulated in hAT2 cells by HSULF-1 over-expression

AT2 cells
Gene symbol	Description	Function	Fold change
BCL2L11	BCL2-like 11 (apoptosis facilitator)	Pro-apoptosis	2.1
CASP7	Caspase 7	Pro-apoptosis	2.1
DAPK1	Death-associated protein kinase 1	Pro-apoptosis	−4.2
TNFRSF9	TNF receptor superfamily member 9	Pro-apoptosis	4.5
BCL2A1	BCL2-related protein A1	Anti-apoptosis	−2
IGF1R	Insulin-like growth factor 1 receptor	Anti-apoptosis	−2.3

hAT2 cells were infected with HSULF-1 adenovirus, total mRNA was isolated, and an Apoptosis PCR array was used to analyze gene expression. Genes that were significantly up- or down- regulated more than 2-fold compared to lacZ adenovirus control are shown.

ISSN: 1465-993X