Skip to main content
Figure 6 | Respiratory Research

Figure 6

From: L-citrulline supplementation reverses the impaired airway relaxation in neonatal rats exposed to hyperoxia

Figure 6

Effect of L-citrulline and inhibition of argininosuccinate synthase (ASS) on TSM relaxation in hyperoxia-exposed rat pups: L-citrulline supplementation (2 mM) reversed the hyperoxia-induced impairment of relaxation of TSM (p < 0.001). The effect of the L-citrulline was lost when TSM was incubated in the presence of argininosuccinate synthase (ASS) inhibitor, α-MDLA (1 mM) (p < 0.05). *Hyperoxia vs. Room air; §Hyperoxia + L-citrulline vs. Hyperoxia; †Hyperoxia + L-citrulline + α-MDLA vs. Hyperoxia + L-citrulline. *p < 0.05; ***p < 0.001; §§§p < 0.001; †p < 0.05 (n = 7 for each protocol of the experiments).

Back to article page

Respiratory Research

ISSN: 1465-993X

Contact us