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Table 2 Side effects of different doses of AZD8848 in healthy subjects (the single ascending dose study): each group comprised four individuals and the figures indicate the number of subjects reporting a particular experience (by preferred term)

From: Repeated intranasal TLR7 stimulation reduces allergen responsiveness in allergic rhinitis

  Dose (μg)
  0.3 1 3 10 30 100 300 600
Headache 1 0 0 1 0 3 3 4
Epistaxis 1 0 0 0 1 1 1 4
Pharyngeal pain 0 0 0 0 1 0 0 3
Pyrexia 0 0 0 0 0 2 1 3
Rhinorrhea 0 0 0 0 0 2 1 2
Nasal blockage 0 0 0 0 2 1 0 0
Nasal ulcer 0 0 0 0 0 0 2 1
Nasopharyngitis 1 0 0 0 0 0 1 0
Malaise 0 0 0 0 0 0 0 1
Myalgia 0 0 0 0 0 1 1 2
  1. The most common event was flu-like symptoms occurring within 24 hours and disappearing within 48 hours. The second most common event was epistaxis, i.e. blood-admixed nasal secretions. The side effects were dose-dependent and considered causally related to the treatment.