Table 2 Side effects of different doses of AZD8848 in healthy subjects (the single ascending dose study): each group comprised four individuals and the figures indicate the number of subjects reporting a particular experience (by preferred term)
From: Repeated intranasal TLR7 stimulation reduces allergen responsiveness in allergic rhinitis
Dose (μg) | ||||||||
|---|---|---|---|---|---|---|---|---|
0.3 | 1 | 3 | 10 | 30 | 100 | 300 | 600 | |
Headache | 1 | 0 | 0 | 1 | 0 | 3 | 3 | 4 |
Epistaxis | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 4 |
Pharyngeal pain | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 3 |
Pyrexia | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 3 |
Rhinorrhea | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 2 |
Nasal blockage | 0 | 0 | 0 | 0 | 2 | 1 | 0 | 0 |
Nasal ulcer | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 1 |
Nasopharyngitis | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Malaise | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Myalgia | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 2 |