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Table 1 Design of the repeat challenge/treatment study (Part A and B)

From: Repeated intranasal TLR7 stimulation reduces allergen responsiveness in allergic rhinitis

Study week 1        2        3        4        5        6  
  1 2 3 4 5 6 7 1 2 3 4 5 6 7 1 2 3 4 5 6 7 1 2 3 4 5 6 7 1 2 3 4 5 6 7 1 2
Treatment X        X        X        X        X         
Allergen                               X X X X X X X  
Symptoms                               X X X X X X X X
Plasma X X              X X              X X        
Nasal lavage X                             X         X
  1. Nasal symptoms were scored ten minutes after each allergen challenge as well as every morning and evening during the seven days’ allergen challenge series. Note that post challenge and evening symptoms were recorded from day 2 of Study week 5 to day 1 of Study week 6, while morning symptoms were recorded from day 3 of Study week 5 to day 2 of Study week 6. On the first days of Study weeks 1 and 5 nasal lavages were carried out prior to administration of the study drug. The plasma samples were used to monitor safety parameters, pharmacokinetics, and IL-1Ra.