Figure 5
From: Inhaled fluticasone propionate impairs pulmonary clearance of Klebsiella Pneumoniae in mice
A Overnight nitric oxide production by murine AM after in vitro stimulation with LPS (100 ng/ml) and rmIFN-γ (100 U/ml). FP pre-treatment (2 h) decreased NO production at 10nM final concentration. n = 6 per group. * p < 0.05 vs. stimulated group without FP. B iNOS mRNA expression in the lungs of mice 90 minutes after i.t. K. pneumoniae challenge. Mice treated with FP for 8 days demonstrated significantly less iNOS mRNA after infection compared to vehicle-treated animals. n = 8 per group. * p < 0.05 vs. vehicle.