Table 4 Positive findings of genetic association analysis in the AAT Genetic Modifiers Study and the UK AATD National Registry
| Â | AAT Genetic Modifiers Study | UK AATD National Registry |
|---|---|---|
All subjects | Association with pre- and post- FEV1% predicted and pre- and post- FEV1/FVC | none |
Interaction with gender | yes | yes |
Interaction with smoking | yes | only in the male subgroup |
Male subgroup | association with FEV1 and FEV1/FVC | association with emphysema association with COPD after adding smoking interaction term |