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Table 1 Participants characteristics

From: Stage-dependent association of BDNF and TGF-β1with lung function in stable COPD

  COPD Control p
  all GOLD 2 GOLD 3 GOLD 4   COPD (all) vs. Control
  n = 63 n = 22 n = 28 n = 13 n = 17
Age 64.0 67.0 63.0 62.0 62.0 0.96
(years) [43…79] [45…78] [43…76] [51…79] [51…73]  
Body Mass Index 24.8 29.4 23.4 23.8 27.4 0.40
(kg*m-2) [13.6…46.5] [19.3…39.7] [13.6…46.5] [15.8…32.0] [22.9…57.1]
pack years 40.0 41.5 42.0 34.0 25.0 < 0.001
  [0…100] [0…100] [18…75] [20…60] [20…40]  
Smoking history       -
never/active/former 2 / 11 / 48 1 / 6 / 14 1 / 5 / 21 0 / 0 / 13 0 / 1 / 16  
Inhaled medication       -
LABA/LAMA/ICS 59 / 58 / 49 21 / 19 / 20 25 / 26 / 18 13 / 13 / 11 0 / 0 / 0  
Oral medication       -
OCS/PDE-I/TPH 13 / 5 / 10 3 / 0 / 2 7 / 2 / 5 3 / 3 / 3 0 / 0 / 0  
Hemoglobin 14.4 14.3 14.7 13.8 11.6 < 0.001
(mg/l) [10.3…16.9] [10.3…16.4] [10.4…16.9] [11.6…16.8] [9.6…14.8]  
Hematocrit 42.4 42.4 42.8 42.0 35.7 < 0.001
(%) [31.1…49.9] [31.1…47.4] [31.1…49.9] [37.6…49.4] [27.8…41.6]  
Platelets 292 239 322 293 289 0.56
(*109/l) [145…787] [172…417] [154…787] [145…504] [177…569]  
Leukocytes 8.6 8.1 9.4 8.7 8.7 0.69
(*109/l) [6.1…18.3] [6.2…11.9] [6.1…18.3] [6.8…17.8] [6.4…11.6]  
FEV 1 total 1.13 1.46 1.11 0.69 2.32 < 0.001
(l) [0.45…2.34] [0.96…2.34] [0.76…1.76] [0.45…0.91] [1.33…4.24]  
FEV 1 % pred. 42.6 58.2 41.1 27.4 76.1 < 0.001
(%) [16.3…76.2] [50.3…76.2] [30.0…48.5] [16.3…29.7] [55.2…145.8]  
FEV 1 % VC 46.9 57.8 45.3 34.5 83.3 < 0.001
(%) [22.2…67.0] [41.7…67.0] [30.2…63.8] [22.2…49.3] [71.0…99.7]  
MEF25 total 0.25 0.31 0.25 0.17 1.02 < 0.001
(l/s) [0.10…0.62] [0.13…0.62] [0.12…0.38] [0.10…0.36] [0.36…4.58]  
MEF25 % pred. 18.8 24.7 17.5 12.9 62.3 < 0.001
(%) [7.3…41.4] [10.9…41.4] [8.8…32.1] [7.3…30.0] [29.6…286.0]  
RV total 4.46 3.62 4.76 6.05 2.60 < 0.001
(l) [2.27…8.48] [2.72…5.37] [2.27…8.48] [3.66…8.26] [1.12…3.76]  
RV % pred. 200.6 158.5 203.6 273.7 113.9 < 0.001
(%) [101.9…376.8] [114.0…240.1] [101.9…376.8] [204.5…317.5] [48.1…146.8]  
TLC total 7.09 6.17 7.21 8.46 5.40 < 0.01
(l) [4.1…14.09] [5.1…8.9] [4.1…11.7] [5.0.…14.1] [3.0…8.2]  
TLC % pred. 116.8 111.1 116.8 135.8 84.5 < 0.001
(%) [71.5…179.2] [83.3…149.1] [71.5…169.5] [107.5…179.2] [52.3…111.0]  
RV % TLC 64.8 57.4 65.2 73.5 50.1 < 0.001
(%) [45.1…86.2] [45.1…70.6] [52.3…73.6] [65.4…86.2] [26.5…63.5]  
TLCO / VA total 0.69 0.84 0.64 0.37 1.03 < 0.001
(mmol/min/kPa/l) [0.01…1.72] [0.37…1.72] [0.13…1.27] [0.01…0.90] [0.72…1.91]  
TLCO / VA % pred. 49.0 60.3 42.3 27.8 77.6 < 0.001
(%) [0.95…105.4] [25.6…105.4] [8.0…89.1] [0.95…68.6] [57.3…138.5]  
  1. Data are shown as median [minimum…maximum]. LABA – long-acting beta agonist, LAMA – long acting muscarinic antagonist, ICD – inhaled corticosteroids, OCS – oral corticosteroids, PDE-I – phosphodiesterase inbibitor, TPH – theophylline.