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Table 2 Studies which report lung function after statin treatment

From: Statins as potential therapeutic drug for asthma?

Study Study type Group Sample (Trial/Control) Duration of treatment Results (statin group compared with the control group)
Ostroukhova et al., [18] Retrospective study Statin exposed vs statin unexposed 50(24/26) 2 years 3% to 5% median worsening of FEV1
Braganza et al., [16] RCT Atorvastatin(40mg/day) vs placebo 71 4weeks No significant difference
Moskovljevicet al., [28] Controlled clinical trial Atorvastatin(10mg/day) vs placebo 9 4 weeks No significant difference
Menzies et al., [21] RCT Simvastatin(20mg/day,40mg/day)vs placebo 16 4 weeks No significant difference
Hothersall et al., [22] RCT Atorvastatin(40mg/day) vs placebo 54 8 weeks No significant difference
Cowan et al., [25] RCT Simvastatin(40mg/day) vs placebo 43 4 weeks PEF, FEV1 (p<0.01) ↑
Pagovich et al., [26] Retrospective study Atorvastatin, simvastatin vs baseline 70 4 weeks PF (p<0.0001) ↑
Foumani et al., [19] RCT Atorvastatin(40mg/day) vs placebo 67 8 weeks No significant difference
Fahimi et al., [23] RCT Atorvastatin(10mg/day) vs placebo 17 4 weeks No significant difference
Feschenko et al., [14] RCT Atorvastatin+ICS+Salbutamol vs ICS+salbutamol 31 4 weeks Morning PEF, FEV1
Adams et al., [27] Retrospective study Statin exposed vs statin unexposed 539 Not mentioned No significant difference
Moini et al., [24] RCT Atorvastatin(40mg/day) vs placebo 62 8 weeks No significant difference
  1. PEF=Peak Expiratory Flow; FEV1= Forced expiratory volume in one second; PF= Peak flow.
  2. ↑ The lung function was improved in statin group compared with the control group, ↓ an opposite result.