Relationship between body composition, inflammation and lung function in overweight and obese asthma

Respiratory Research

Table 5 Relationship between body composition and systemic inflammation (leptin, CRP), airway inflammation and airway hyperresponsiveness in females.

	Leptin (pg/mL)	CRP (pg/mL)	Neutrophils (%)	Neutrophils (× 10⁴/mL)	Eosinophils (%)	Eosinophils (× 10⁴/mL)	Dose Response Slope †
Weight (kg)	0.391	0.199	0.218	0.263	-0.370	-0.291	-0.196
Waist Circumference (cm)	0.349	0.048	0.285	0.306	-0.125	-0.229	-0.045
Fat Mass (g)
Total	0.415	0.211	-0.040	-0.072	-0.506*	-0.385	-0.270
Android	0.260	0.240	0.029	0.068	-0.333	-0.315	-0.113
Gynoid	0.316	0.168	-0.115	0.032	-0.650**	-0.298	-0.480*
Thoracic	0.244	0.156	0.017	0.011	-0.413	-0.459	-0.209
Arms	0.317	0.036	0.026	-0.015	-0.031	-0.209	0.021
Legs	0.315	0.067	0.044	0.199	-0.438	-0.129	-0.362
Lean Mass (g)
Total	0.288	0.225	0.461	0.408	-0.048	-0.109	-0.060
Android	0.205	0.243	0.322	0.279	-0.042	-0.115	-0.122
Gynoid	0.232	0.247	0.544*	0.555*	-0.159	-0.038	-0.125
Thoracic	0.193	0.180	0.323	0.273	-0.149	-0.227	-0.127
Arms	0.277	0.111	0.227	0.171	-0.077	-0.231	0.270
Legs	0.309	0.045	0.709***	0.696**	0.070	0.119	0.087
%Fat
Total	0.216	0.110	-0.474*	-0.349	-0.448	-0.324	-0.296
Android	0.166	0.112	-0.298	-0.205	-0.353	-0.263	-0.050
Gynoid	0.188	0.103	-0.441	-0.337	-0.512*	-0.279	-0.451*
Thoracic	0.082	0.072	-0.306	-0.287	-0.334	-0.340	-0.133
Arms	0.317	-0.015	-0.076	-0.087	0.017	-0.094	-0.146
Legs	0.147	0.095	-0.345	-0.231	-0.445	-0.251	-0.420

CRP - C-reactive protein. Partial correlations are adjusted for height, age and pack years. * p≤0.05; ** p≤0.01; *** p≤0.001. † Provocation fall (%) ÷ provocation dose of 4.5% hypertonic saline (mL), after hypertonic saline challenge.

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