Figure 1
From: Therapeutic efficacy of TBC3711 in monocrotaline-induced pulmonary hypertension
Effect of TBC3711 on hemodynamics in monocrotaline (MCT)-induced pulmonary hypertension. Rats were treated with TBC3711 (n = 14) or vehicle (n = 9) from day 21-35 after MCT-injection. TBC3711 (MCT-TBC3711, 30 mg/kg body weight/day) was administered once per day orally by gavage. Equal volume of the vehicle (methyl-cellulose) was given to a placebo group (MCT-placebo). After 35 days all animals were humanely killed for hemodynamic measurements. (a) Right ventricular systolic pressure (RVSP) and (b) Systemic arterial pressure (SAP) are given. Bars represent mean ± SEM. One-way ANOVA with Newman-Keuls multiple comparison post-hoc test was performed for statistical analysis. ***P < 0.001.