Figure 7
From: Epithelial cell senescence impairs repair process and exacerbates inflammation after airway injury
The telomerase inhibitor MST-312 induces cellular senescence and pro-inflammatory cytokine production. NCI-H441 cells were cultured for 28 days in the presence (closed circles) or absence (open circles) of 2.5 μM MST-312, with passages every 7 days. (A) Population doubling of NCI-H441 cells exposed and not exposed to the telomerase inhibitor. (B) Concentrations of pro-inflammatory cytokines in the culture supernatants. Data are expressed as the means ± SEM. *P < 0.05 and **P < 0.01 vs. cells not exposed to BrdU. N = 3-5 in each group.